Colby and Sam have been best friends since they were kids. Now that they're 15, things are starting to change. They live near the eponymous creek and spend all their time together. They also grew up with Colby's friend, Petey.
- Colby (proto-Dawson)
- Samantha "Sam" (proto-Joey)
- Petey (proto-Pacey)
The show is based on an independent film directed by Dawson Leery in Spring 2003, which caught the interest of the network and was subsequently developed into a series. Leery is the showrunner on the series, which is shoot and produced in Los Angeles, California.